Low-frequency HIV-1 drug resistance mutations can be clinically significant but must be interpreted with caution

Low-frequency HIV-1 drug resistance mutations can be clinically significant but must be interpreted with caution.

With drug-resistant HIV-1 present in at least 10%-20% of new infections in Western countries and in >60% of patients failing antiretroviral therapy (ART), monitoring HIV-1 drug resistance is becoming increasingly important for assessing its impact on therapeutic measures of virus control and for guiding treatment. The sensitivity limitations of conventional bulk genotyping often lead to an unde...

Clinically Significant Rhinosinusitis Can Be Asymptomatic.

Genetic variants in pre-eclampsia should be interpreted with caution.

Genetic variants in pre-eclampsia should be interpreted with caution Sir, We read the article entitled 'Genetic variants in pre-eclampsia: a meta-analysis' by Buurma et al. (2013) with great interest. It is an important step forward in the identification of genetic variants associated with pre-eclampsia. However, there are several important issues that require clarification or further research....

Ischemia-modified albumin concentrations should be interpreted with caution in patients with low serum albumin concentrations.

OBJECTIVE Ischemia-modified albumin (IMA((R))) is a novel marker for assessing cardiac ischaemia. We assessed the relationship between total albumin concentrations and IMA in serum to investigate whether interpretation of IMA was albumin-dependent. SUBJECTS AND METHODS 298 serum samples were assayed for total albumin (albumin), using bromcresol purple, and IMA, using an indirect colorimetric ...

Response to "Clinically Significant Rhinosinusitis Can Be Asymptomatic".